Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis.
Identifieur interne : 003759 ( Main/Exploration ); précédent : 003758; suivant : 003760Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis.
Auteurs : C S Zipitis [Royaume-Uni] ; A K AkobengSource :
- Archives of disease in childhood [ 1468-2044 ] ; 2008.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Carence en vitamine D (diétothérapie), Carence en vitamine D (immunologie), Diabète de type 1 (diétothérapie), Diabète de type 1 (prévention et contrôle), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Facteurs âges (MeSH), Humains (MeSH), Nourrisson (MeSH), Relation dose-effet des médicaments (MeSH), Vitamine D (administration et posologie), Vitamines (administration et posologie), Études cas-témoins (MeSH).
- MESH :
- administration et posologie : Vitamine D, Vitamines.
- diétothérapie : Carence en vitamine D, Diabète de type 1.
- immunologie : Carence en vitamine D.
- prévention et contrôle : Diabète de type 1.
- Adolescent, Enfant, Enfant d'âge préscolaire, Facteurs âges, Humains, Nourrisson, Relation dose-effet des médicaments, Études cas-témoins.
English descriptors
- KwdEn :
- Adolescent (MeSH), Age Factors (MeSH), Case-Control Studies (MeSH), Child (MeSH), Child, Preschool (MeSH), Diabetes Mellitus, Type 1 (diet therapy), Diabetes Mellitus, Type 1 (prevention & control), Dose-Response Relationship, Drug (MeSH), Humans (MeSH), Infant (MeSH), Vitamin D (administration & dosage), Vitamin D Deficiency (diet therapy), Vitamin D Deficiency (immunology), Vitamins (administration & dosage).
- MESH :
- chemical , administration & dosage : Vitamin D, Vitamins.
- diet therapy : Diabetes Mellitus, Type 1, Vitamin D Deficiency.
- immunology : Vitamin D Deficiency.
- prevention & control : Diabetes Mellitus, Type 1.
- Adolescent, Age Factors, Case-Control Studies, Child, Child, Preschool, Dose-Response Relationship, Drug, Humans, Infant.
Abstract
OBJECTIVES
To assess whether vitamin D supplementation in infancy reduces the risk of type 1 diabetes in later life.
METHODS
This was a systematic review and meta-analysis using Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles. The main outcome measure was development of type 1 diabetes. Controlled trials and observational studies that had assessed the effect of vitamin D supplementation on risk of developing type 1 diabetes were included in the analysis.
RESULTS
Five observational studies (four case-control studies and one cohort study) met the inclusion criteria; no randomised controlled trials were found. Meta-analysis of data from the case-control studies showed that the risk of type 1 diabetes was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented (pooled odds ratio 0.71, 95% CI 0.60 to 0.84). The result of the cohort study was in agreement with that of the meta-analysis. There was also some evidence of a dose-response effect, with those using higher amounts of vitamin D being at lower risk of developing type 1 diabetes. Finally, there was a suggestion that the timing of supplementation might also be important for the subsequent development of type 1 diabetes.
CONCLUSION
Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes. The evidence for this is based on observational studies. Adequately powered, randomised controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation.
DOI: 10.1136/adc.2007.128579
PubMed: 18339654
Affiliations:
Links toward previous steps (curation, corpus...)
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xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatrics, Stockport NHS Foundation Trust, Poplar Grove, Stockport SK2 7JE</wicri:regionArea><wicri:noRegion>Stockport SK2 7JE</wicri:noRegion></affiliation></author><author><name sortKey="Akobeng, A K" sort="Akobeng, A K" uniqKey="Akobeng A" first="A K" last="Akobeng">A K Akobeng</name></author></analytic><series><title level="j">Archives of disease in childhood</title><idno type="eISSN">1468-2044</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Age Factors (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Diabetes Mellitus, Type 1 (diet therapy)</term><term>Diabetes Mellitus, Type 1 (prevention & control)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Vitamin D (administration & dosage)</term><term>Vitamin D Deficiency (diet therapy)</term><term>Vitamin D Deficiency (immunology)</term><term>Vitamins (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Carence en vitamine D (diétothérapie)</term><term>Carence en vitamine D (immunologie)</term><term>Diabète de type 1 (diétothérapie)</term><term>Diabète de type 1 (prévention et contrôle)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Humains (MeSH)</term><term>Nourrisson (MeSH)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Vitamine D (administration et posologie)</term><term>Vitamines (administration et posologie)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vitamin D</term><term>Vitamins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vitamine D</term><term>Vitamines</term></keywords><keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Diabetes Mellitus, Type 1</term><term>Vitamin D Deficiency</term></keywords><keywords scheme="MESH" qualifier="diétothérapie" xml:lang="fr"><term>Carence en vitamine D</term><term>Diabète de type 1</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Carence en vitamine D</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Vitamin D Deficiency</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Diabetes Mellitus, Type 1</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Diabète de type 1</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Age Factors</term><term>Case-Control Studies</term><term>Child</term><term>Child, Preschool</term><term>Dose-Response Relationship, Drug</term><term>Humans</term><term>Infant</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs âges</term><term>Humains</term><term>Nourrisson</term><term>Relation dose-effet des médicaments</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To assess whether vitamin D supplementation in infancy reduces the risk of type 1 diabetes in later life.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This was a systematic review and meta-analysis using Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles. The main outcome measure was development of type 1 diabetes. Controlled trials and observational studies that had assessed the effect of vitamin D supplementation on risk of developing type 1 diabetes were included in the analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Five observational studies (four case-control studies and one cohort study) met the inclusion criteria; no randomised controlled trials were found. Meta-analysis of data from the case-control studies showed that the risk of type 1 diabetes was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented (pooled odds ratio 0.71, 95% CI 0.60 to 0.84). The result of the cohort study was in agreement with that of the meta-analysis. There was also some evidence of a dose-response effect, with those using higher amounts of vitamin D being at lower risk of developing type 1 diabetes. Finally, there was a suggestion that the timing of supplementation might also be important for the subsequent development of type 1 diabetes.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes. The evidence for this is based on observational studies. Adequately powered, randomised controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18339654</PMID><DateCompleted><Year>2008</Year><Month>06</Month><Day>20</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-2044</ISSN><JournalIssue CitedMedium="Internet"><Volume>93</Volume><Issue>6</Issue><PubDate><Year>2008</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Archives of disease in childhood</Title><ISOAbbreviation>Arch Dis Child</ISOAbbreviation></Journal><ArticleTitle>Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis.</ArticleTitle><Pagination><MedlinePgn>512-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/adc.2007.128579</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To assess whether vitamin D supplementation in infancy reduces the risk of type 1 diabetes in later life.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a systematic review and meta-analysis using Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles. The main outcome measure was development of type 1 diabetes. Controlled trials and observational studies that had assessed the effect of vitamin D supplementation on risk of developing type 1 diabetes were included in the analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Five observational studies (four case-control studies and one cohort study) met the inclusion criteria; no randomised controlled trials were found. Meta-analysis of data from the case-control studies showed that the risk of type 1 diabetes was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented (pooled odds ratio 0.71, 95% CI 0.60 to 0.84). The result of the cohort study was in agreement with that of the meta-analysis. There was also some evidence of a dose-response effect, with those using higher amounts of vitamin D being at lower risk of developing type 1 diabetes. Finally, there was a suggestion that the timing of supplementation might also be important for the subsequent development of type 1 diabetes.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes. The evidence for this is based on observational studies. Adequately powered, randomised controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zipitis</LastName><ForeName>C S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Department of Paediatrics, Stockport NHS Foundation Trust, Poplar Grove, Stockport SK2 7JE, UK. czipitis@hotmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akobeng</LastName><ForeName>A K</ForeName><Initials>AK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D016454">Review</PublicationType><PublicationType UI="D000078182">Systematic Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Arch Dis Child</MedlineTA><NlmUniqueID>0372434</NlmUniqueID><ISSNLinking>0003-9888</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014815">Vitamins</NameOfSubstance></Chemical><Chemical><RegistryNumber>1406-16-2</RegistryNumber><NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003922" MajorTopicYN="N">Diabetes Mellitus, Type 1</DescriptorName><QualifierName UI="Q000178" MajorTopicYN="N">diet therapy</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014807" MajorTopicYN="N">Vitamin D</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014808" MajorTopicYN="N">Vitamin D Deficiency</DescriptorName><QualifierName UI="Q000178" MajorTopicYN="N">diet therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014815" MajorTopicYN="N">Vitamins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>38</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>3</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>6</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>3</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18339654</ArticleId><ArticleId IdType="pii">adc.2007.128579</ArticleId><ArticleId IdType="doi">10.1136/adc.2007.128579</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Akobeng, A K" sort="Akobeng, A K" uniqKey="Akobeng A" first="A K" last="Akobeng">A K Akobeng</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Zipitis, C S" sort="Zipitis, C S" uniqKey="Zipitis C" first="C S" last="Zipitis">C S Zipitis</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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